Adrenocorticotropin-lipotropin precursor gene

US4322499A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• John D. Baxter · West Melbourne, US
• James L. Roberts · San Francisco, US
• Peter H. Seeburg · San Francisco, US
• Howard Goodman · Newtown, US
• John Shine · Fawn Drive, AU

Key dates

• Filing date: Dec 22, 1978
• Grant date: Mar 30, 1982
• Expiry date: Dec 22, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/665
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A technique suitable for cloning a cDNA having a base sequence coding for the ACTH/LPH precursor is disclosed. The invention is exemplified by the cloning of a cDNA fragment comprising a base sequence coding for the endorphin region. The fragment, hereinafter termed the endorphin gene cDNA sequence, was obtained from cultured mouse pituitary tumor cells known to produce the ACTH/LPH precursor protein.