Method of preparing gamma-L-glutamyl taurine
US4324743A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1977 |
| Grant date | Apr 13, 1982 |
| Priority date | — |
| Expiry date | Jul 11, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q17/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing gamma-L-glutamyl-taurine, which has been found to be effective therapeutically through the control of vitamin A metabolism, which comprises reacting carbobenzyloxy-L-glutaminic acid-.alpha.-benzyl ester with triethylamine and isobutylchloroformate and then treating the reaction mixture with cystamine dihydrochloride to recover N,N'-bis-(N-carbobenzyloxy-gamma-[.alpha.-benzyl]-L-glutamyl)-cystamine. The latter is reacted with hydrogen peroxide in glacial acetic acid to produce carbobenzyloxy-gamma-(.alpha.-benzyl)-L-glutamyl taurine. The latter compound is treated with hydrogen bromide in glacial acetic acid to recover the gamma-(.alpha.-benzyl)-L-glutamyl taurine and this compound is treated with potassium hydroxide solution to yield the gamma-L-glutamyl taurine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.