Antipsychotic tetrahydropyridinyl-indoles, compositions and method of use
US4324790A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1980 |
| Grant date | Apr 13, 1982 |
| Priority date | — |
| Expiry date | Jun 30, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel tetranydro-pyridinyl-indoles of the formula ##STR1## wherein X is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 3 to 5 carbon atoms, cycloalkyl of 5 to 6 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, aralkyl of 7 to 12 carbon atoms, hydroxyalkyl of 2 to 5 carbon atoms and phenoxyalkyl of 1 to 5 alkyl carbon atoms, R is selected from the group consisting of hydrogen, halogen, alkoxy of 1 to 3 carbon atoms, nitro, amino, trifluoromethyl and methylthio, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms with the proviso that if R is hydrogen, halogen or alkoxy of 1 to 3 carbon atoms, X must be hydroxyalkyl or phenoxyalkyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, antipsychotic and antiemetic activity and their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.