Process for the production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid

US4327039A · kind A · utility

Assignee

• Henkel Kommanditgesellschaft auf Aktien (Henkel KGAA) · DE

Inventors

• Helmut Blum · Goldkronach, DE
• Karl-Heinz Worms

Key dates

• Filing date: Oct 1, 1980
• Grant date: Apr 27, 1982
• Expiry date: Oct 1, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3873
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and lower alkyl, consisting essentially of the steps of reacting a .beta.-alanine compound selected from the group consisting of .beta.-alanine and lower alkylated .beta.-alanine with a phosphonating reactant selected from the group consisting of: PA0 (1) a mixture of phosphorous acid and PCl.sub.5, and PA0 (2) a mixture of phosphorous acid, PCl.sub.3 and Cl.sub.2, hydrolyzing the reaction mixture, and recovering said 3-amino-1-hydroxypropane-1,1-diphosphonic acid.