Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
US4328214A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 25, 1980 |
| Grant date | May 4, 1982 |
| Priority date | — |
| Expiry date | Jun 25, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The somatostatin-analogous cyclic octapeptides according to the invention of the general formula ##STR1## in which trp represents L-Trp or D-Trp, in which the benzene ring may be substituted by a halogen atom, and PA1 Gaba(Ar) represents the residue of a .gamma.-aminobutyric acid substituted by a cyclic hydrocarbyl radical, and their acid addition salts and complexes are distinguished by a strong inhibition of the insulin and glucagon secretion of the pancreas and are therefore therapeutically acceptable, preferably in the form of pharmaceutical preparations, in similar indications to those of somatostatin, especially as anti-diabetics. The compounds are manufactured by conventional processes of peptide synthesis, especially by liberation from corresponding protected intermediates after intramolecular cyclization of a corresponding linear octapeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.