Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril

US4329347A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Erich Muller · Zell am Harmersbach, DE
• Josef Nickl
• Josef Roch · Biberach, DE
• Berthold Narr · Biberach, DE
• Walter Haarmann
• Johannes Weisenberger · Biberach, DE

Key dates

• Filing date: Jul 24, 1980
• Grant date: May 11, 1982
• Expiry date: Jul 24, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein W is vinylene, methyl-vinylene, methylene or ethylene; PA0 m is 0, 1 or 2; PA0 D is straight or branched alkylene of 2 to 6 carbon atoms, straight or branched hydroxy-alkylene of 3 to 6 carbon atoms, or xylylene; PA0 R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; PA0 R.sub.2 is cycloalkyl of 3 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 11 carbon atoms, heteroaryl, heteroarlkyl, 1,2,4-triazolyl, triphenylmethyl, 4,5-bis-(p-chlorophenyl)-oxazol-2-yl, N-methyl-cyclohexylamino-carbonylmethyl,-amino-iminomethyl or, when m is 1 or D is hydroxyalkylene or xylylene, also alkyl of 1 to 6 carbon atoms; and PA0 R.sub.3 and R.sub.4 are each hydrogen, halogen, alkyl of 1 to 4 carbon atoms, amino, acetylamino or nitro. The compounds of the invention are useful as cardiotonics and as antithrombotics.