Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof
US4330539A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1981 |
| Grant date | May 18, 1982 |
| Priority date | — |
| Expiry date | Jan 29, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0068
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: PA0 R.sub.1 =H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); PA0 R.sub.2 =H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); PA0 R.sub.3 =a free, esterified or etherified hydroxyl group; ring A inclusive carbon atoms 6 and 9 has one of the following configurations: ##STR2## in which R.sub.4 =a free, esterified or etherified hydroxyl group; PA0 R.sub.5 =O or H(R.sub.7), wherein R.sub.7 is a free, esterified or etherified hydroxyl group; PA0 R.sub.6 =H or methyl; and PA0 the dotted lines represent an optional double bond in 4,5- or 5,6-position; as well as the enantiomers and racemates of these steroids. The novel compounds have antiarrhythmic properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.