7-Oxo-PGI.sub.2 -derivatives and process for the preparation thereof and pharmaceutical compositions containing same
US4330553A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 1980 |
| Grant date | May 18, 1982 |
| Priority date | — |
| Expiry date | Nov 10, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/937
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New PGI.sub.2 derivatives and a process for their preparation are disclosed of the formula (I) ##STR1## wherein Q is hydrogen, a pharmacologically acceptable cation, or lower alkyl; PA1 A is cis or trans --CH.dbd.CH--, --C.tbd.C--, or --CH.sub.2 --CH.sub.2 --; PA1 R.sup.13 is hydrogen or a C.sub.1 to C.sub.4 alkanoyl or is a blockinggroup of the formula R.sup.7 R.sup.8 R.sup.9 Si or ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 are the same or different and can be straight or branched chain alkyl groups having 1 to 4 carbon atoms and R.sup.10 and R.sup.11 are the same or different and can be hydrogen or methyl, and R.sup.12 represents methyl or ethyl, or is tetrahydropyran-2-yl; PA1 R.sup.4 is hydrogen or lower alkyl inthe .alpha. or .beta. steric position; PA1 R.sup.1 and R.sup.2 are each hydrogen or lower alkyl; PA1 Y is methylene, oxygen or an --NH-- group; and PA1 R.sup.3 is lower alkyl or phenyl which can be monosubstituted phenyl. The compounds are useful as antiaggregation or thrombus-dissolving agents, stomach juice secretion inhibiting agents and antiasthmatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.