Sparingly water-soluble salts of penicillanic acid 1,1-dioxide
US4331599A · kind A · utility
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2Claims
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Key dates
| Filing date | Feb 2, 1981 |
| Grant date | May 25, 1982 |
| Priority date | — |
| Expiry date | Feb 2, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The 1:2 N,N'-dibenzylethylenediamine, the N-benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known betalactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.