Cephem and cepham compounds

US4331665A · kind A · utility

Assignee

• Fujisawa Pharmaceutical Co., Ltd. · JP

Inventors

• Tsutomu Teraji · Osaka, JP
• Kazuo Sakane · Kawanishi, JP
• Jiro Goto

Key dates

• Filing date: Mar 7, 1980
• Grant date: May 25, 1982
• Expiry date: Mar 7, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/21
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

7-Substituted-3-cephem and cepham-4-carboxylic acids represented by the following formula (I): ##STR1## wherein R.sup.1 is amino or a protected amino, PA1 R.sup.2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower)alkenyl, or S or O containing 5-membered heterocyclic group substituted with oxo group(s), PA1 R.sup.3 is hydrogen or lower alkyl, PA1 R.sup.4 is hydrogen; acyloxy(lower)alkyl); acylthio(lower)alkyl; pyridinium(lower)alkyl which may be substituted with suitable substituent(s); a heterocyclicthio(lower)alkyl which may be substituted with suitable substituent(s); lower alkyl; halogen; or hydroxy; and, PA1 R.sup.5 is carboxy or a protected carboxy, wherein R.sup.5 is COO.sup.- when R.sup.4 is pyridinium(lower)alkyl which may be substituted with suitable substituent(s), and the heavy solid line means single or double bond, are useful as antibiotics.