Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
US4331697A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 2, 1980 |
| Grant date | May 25, 1982 |
| Priority date | — |
| Expiry date | Sep 2, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L33/0011
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; a method for producing aforesaid heparin derivative which comprises reacting heparin with a halide or anhydride of an unsaturated carboxylic acid of the formula ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are the same as defined above; and a method for imparting antithrombotic activity to a biomedical material, which comprises treating that surface of the biomedical material which makes contact with the blood with actinic light in the presence of aforesaid heparin derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.