7-Amino-thia-diazole oxyimino derivatives of cephem and cephem compounds

US4332798A · kind A · utility

Assignee

• Fujisawa Pharmaceutical Co., Ltd. · JP

Inventors

• Tsutomu Teraji · Osaka, JP
• Kazuo Sakane · Kawanishi, JP
• Jiro Goto

Key dates

• Filing date: Jan 30, 1980
• Grant date: Jun 1, 1982
• Expiry date: Jan 30, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/21
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

7-Substituted-3-cephem and cepham-4-carboxylic acids of formula (I) ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower)alkenyl, or S- or O-containing 5-membered heterocyclic group substituted with oxo group(s). PA0 R.sup.3 is hydrogen or lower alkyl, PA0 R.sup.4 is hydrogen; acyloxy(lower)alkyl; acylthio(lower)alkyl pyridinium(lower)alkyl which may be substituted with suitable substituent(s); a heterocyclicthio(lower)alkyl which may be substituted with suitable substituent(s); lower alkyl; halogen; or hydroxy; and PA0 R.sup.5 is carboxy or a protected carboxy wherein R.sup.5 is COO-- when R.sup.4 is pyridinium(lower)alkyl which may be substituted with suitable substituent(s), and the heavy solid line means single or double bond, have useful antibiotic properties.