3-Oxo-pregna-1,14,17-trien-20-carboxylates and process

US4333880A · kind A · utility

Assignee

• Henkel Kommanditgesellschaft auf Aktien (Henkel KGAA) · DE

Inventors

• Wolfgang Preuss · Monheim, DE
• Michael Bahn · Hilden, DE
• Rolf Schmid · Gelterkinden, CH
• Rudiger Wagner · Monheim, DE

Key dates

• Filing date: Jan 26, 1981
• Grant date: Jun 8, 1982
• Expiry date: Jan 26, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J9/005
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A .DELTA..sup.1,4,17 -BNC compound having the formula: ##STR1## wherein X is a substituent selected from the group consisting of OH and OCH.sub.3 ; as well as its process of production by microbiological side-chain splitting of a 17-C-side-chain steroid with a defect mutant microorganism which gives a steroid with a 17-C-.alpha.-propionic acid substituent in the absence of inhibitors inhibiting either the cleavage of the steroid ring or microorganism growth, where the defect mutant microorganisms are grown under a reduced air supply whereby an enrichment of .DELTA..sup.1,4,17 -BNC occurs.