Anti-depressant and analgesic 4-phenoxypiperidines

US4333942A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventors

• Klaus Eistetter · Konstanz, DE
• Hans-Peter Kley · Allensbach, DE
• Heinz-Gunter Menge
• Hartmann Schaefer

Key dates

• Filing date: Jul 11, 1980
• Grant date: Jun 8, 1982
• Expiry date: Jul 11, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/94
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Phenoxypiperidines of the general formula I ##STR1## wherein R.sup.1 denotes a hydrogen atom, an alkyl group with 1 to 5 carbon atoms, an alkenyl group with 3 to 5 carbon atoms, a cycloalkylmethyl group with 3 to 7 carbon atoms in the cycloalkyl part or a phenylalkyl group with 1 to 3 carbon atoms in the alkyl part, PA1 R.sup.2 denotes a hydrogen atom, a nitro group, an amino group or an acylamino group and PA1 R.sup.3 denotes a phenyl group or a benzyl group, and their N-oxides and their acid-addition salts are new compounds. They have an antiptotic and analgesic action and are suitable for the treatment of depressions and painful conditions. Processes for the preparation of the new compounds are provided.