Cephalosporin intermediates
US4334065A · kind A · utility
3Cited by
1References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 24, 1980 |
| Grant date | Jun 8, 1982 |
| Priority date | — |
| Expiry date | Nov 24, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
7.alpha.-(Dimethylamidino)-3-cephem ester 1.alpha.-oxides represented by the formula ##STR1## wherein R is hydrogen or acetoxy and R.sub.1 is a carboxy protecting group, are prepared via DBU epimerization of the corresponding 7.beta.-isomer. When R is hydrogen the intermediates are useful in the preparation of the 7.beta.-acylamino-7.alpha.-methoxy-1-oxa-.beta.-lactam antibiotics, and when R is acetoxy the compounds are intermediates to 7.beta.-acylamino-7.alpha.-methoxy-3-exomethylenecepham compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.