Process for the preparation of an alkyl 2-chloropropionate by chlorinating an alkyl lactate
US4334083A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 1980 |
| Grant date | Jun 8, 1982 |
| Priority date | — |
| Expiry date | May 21, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/307
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A racemic or optically active alkyl 2-chloropropionate is prepared, respectively, from a racemic or optically active alkyl lactate by, in a first step, gradually bringing the alkyl lactate into contact with the thionyl chloride, in the presence of an organic base, while maintaining, in the reaction mixture, an excess of thionyl chloride, relative to the amount of alkyl lactate introduced into this mixture, at a temperature below the decomposition point of the chlorosulphinate of the alkyl lactate, which is formed as an intermediate, and then, in a second step, in heating the reaction mixture resulting from the first step at a temperature which is at least equal to the decomposition point of the chlorosulphinate of the alkyl lactate. The alkyl 2-chloropropionates can be used for the manufacture of the racemic or optically active 2-phenoxypropionic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.