Stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and process for the preparation thereof
US4335097A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1981 |
| Grant date | Jun 15, 1982 |
| Priority date | — |
| Expiry date | Jan 15, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/557
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and a process for the preparation thereof. The tablets according to the invention comprise 0.2 to 20% by weight of one or more natural or synthetic prostaglandins, 0.4 to 40% by weight of a non-toxic buffer, which adjusts the pH of the liquid film formed on the surface of the solid phase due to air humidity, to 3 to 5, 1 to 50% by weight of stearic acid, 0 to 15% by weight of an alkali earth metal stearate, 10 to 95% by weight of lactose and/or mannite, 0 to 15% by weight of a further granulation aid, 1 to 30% by weight of a disintegrating agent and optionally 0.5 to 10% by weight of a flavoring and aroma substance and are prepared under a pressure of 500 to 2000 kp./cm.sup.2. (49.03 to 196.13 MPa).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.