Cytostatic terminally bifunctional sugar alcohols process for preparing them and pharmaceutical compositions containing them
US4337266A · kind A · utility
Inventors
Key dates
| Filing date | Aug 14, 1980 |
| Grant date | Jun 29, 1982 |
| Priority date | — |
| Expiry date | Aug 14, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C43/137
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel anticarcinogenic compounds of formula I, ##STR1## wherein R.sup.1 is halogen PA1 R.sup.2 is hydroxy or PA1 R.sup.1 and R.sup.2 together form an oxygen bridge, PA1 R.sup.3 is methyl, PA1 R.sup.4 is hydrogen, methyl or acyl, PA1 n is 1 or zero, with the provisos, that in case n is 1 the steric positions of --R.sup.2, OR.sup.3 and --OR.sup.4 groups correspond to dulcitol, mannitol or sorbitol configurations independently of their actual meanings, in case n is zero the steric positions of --R.sup.2 and --OR.sup.3 groups correspond to xylitol configuration independently of their actual meanings. The novel compounds can be used as antitumor agents in themselves or formulated as pharmaceutical preparations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.