Modified lithium aluminum hydrides
US4338255A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1981 |
| Grant date | Jul 6, 1982 |
| Priority date | — |
| Expiry date | Feb 25, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/069
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel modified lithium aluminum hydride type reducing agents obtained by reacting one equivalent of lithium aluminum hydride with one equivalent of an optically active N-substituted ephedrine of the formula, ##STR1## (wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or benzyl group, and Ph is phenyl group) and two equivalents of an N-substituted aniline of the formula, ##STR2## (wherein R.sub.2 is C.sub.1 -C.sub.4 alkyl group or phenyl group, and Ph is phenyl group). This reducing agent is usable for reducing the organic compounds having a carbonyl group (ketone group or aldehyde group) in their structure into the corresponding alcohols. It is particularly useful as a reducing agent for asymmetrically reducing the unsymmetrical ketones to selectively produce either an alcohol in which the asymmetric carbon atom bonded to the hydroxy group is in R-configuration or an alcohol in which said asymmetric carbon atom is in S-configuration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.