[1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers

US4338314A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Hans Liepmann · Hannover, DE
• Rolf Hueschens · Hannover, DE
• Wolfgang Milkowski
• Horst Zeugner
• Insa Hell · Hannover, DE
• Klaus-Ullrich Wolf · Burgdorf, DE

Key dates

• Filing date: Aug 16, 1979
• Grant date: Jul 6, 1982
• Expiry date: Aug 16, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of [1,2]anellated-7-phenyl-1,4-benzodiazepines having the formula I ##STR1## wherein X is oxygen, sulfur or NR; PA1 R is H, PA1 C.sub.1 -C.sub.5 alkyl, PA1 C.sub.1 -C.sub.5 alkyl, substituted with a terminal phenyl group, which is unsubstituted or substituted by one or 2 methoxy groups, a 3,4-methylene dioxy or 3,4-ethylenedioxy group, PA1 C.sub.2 -C.sub.5 alkyl, substituted with terminal halogen, hydroxy or methoxy or, PA1 C.sub.3 -C.sub.5 alkenyl PA1 R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are H, halogen, trifluoromethyl, nitro, alkyl, alkoxy, or alkylthio wherein alkyl is C.sub.1 -C.sub.4 alkyl or two neighboring groups represent a methylenedioxy or ethylenedioxy group and the acid addition salts thereof, ulcer treating pharmaceutical compositions containing these compounds and a method of medical treatment using same.