Antimicrobial aminopyrimidinium salts

US4339453A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Nathaniel Grier · Englewood, US
• Elbert E. Harris · Westfield, US
• Henry Joshua · Staten Island, US
• Arthur A. Patchett · Westfield, US
• Bruce E. Witzel · Westfield, US
• Richard A. Dybas · Somerville, US

Key dates

• Filing date: Jul 23, 1979
• Grant date: Jul 13, 1982
• Expiry date: Jul 23, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/48
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Amino- and 2,4-diaminopyrimidines with a quaternized ring nitrogen and an oxygen bearing substituent such as hydroxyalkyl, alkoxyalkyl, or alkanoyl on one of the exo- or endocyclic nitrogens and a C.sub.6-18 alkyl on another, are highly active antimicrobial agents with a relatively low acute mammalian toxicity.