Cytotoxic products formed by covalent bonding of the A chain of ricin with an antibody and the process for their preparation and use
US4340535A · kind A · utility
80Cited by
2References
14Claims
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Key dates
| Filing date | Sep 27, 1979 |
| Grant date | Jul 20, 1982 |
| Priority date | — |
| Expiry date | Sep 27, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognizing a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the A chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.