Method for making an IUD with shrinking of a medicated attachment onto a support
US4341728A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1979 |
| Grant date | Jul 27, 1982 |
| Priority date | — |
| Expiry date | Dec 20, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0039
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method for making a medicated IUD including a preexisting contraceptive intrauterine platform and an attachment formed as a cylindrical sleeve of base polymer containing a drug such as an antifertility agent. Local controlled release administration of the drug is added to the contraceptive effect of the preexisting platform. The IUD attachment can be made by centrifuging a medical grade of RTV silicone rubber to remove reinforcing fillers therefrom. A selected quantity of the drug is mixed into the fillerless silicone rubber, and the drug and silicone mixture is injected into a multicavity mold. After the mixture sets and the sleeves are removed from the mold, the sleeves are trimmed, then swollen by immersion in a solvent, and slipped onto a stem of the chosen IUD to shrink about the stem. An outer covering over the sleeve can control the drug release rate and impart greater strength to the fillerless silicone rubber of the attachment. The outer covering can be a tube likewise swollen and slipped onto the sleeve to tightly shrink thereon. The multicavity mold has two clamped-together plates with aligned half cavities, an injection opening adapted to fit an injection syringe and al…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.