3,1 Benzoxazin-2-ones and use thereof

US4341778A · kind A · utility

Assignee

• C. H. Boehringer Sohn · DE

Inventors

• Anton Mentrup · Mainz, DE
• Kurt Schromm · Ingelheim am Rhein, DE
• Ernst-Otto Renth · Ingelheim am Rhein, DE
• Wolfgang Hoefke · Wiesbaden, DE
• Wolfram Gaida · Ingelheim am Rhein, DE
• Ilse Streller · Stromberg, DE
• Armin Fugner · Gau-Algesheim, DE

Key dates

• Filing date: Jul 6, 1981
• Grant date: Jul 27, 1982
• Expiry date: Jul 6, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of general formula I ##STR1## (wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group; PA1 R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen, fluorine or chlorine atom or a hydroxy, methyl, ethyl or (C.sub.1 -C.sub.4) alkoxy group, or R.sub.3 together with R.sub.4 represents a methylenedioxy group; PA1 R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a methyl group; PA1 R.sub.7 represents a group of formula ##STR2## R represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group; R.sub.8 represents a fluorine or chlorine atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkylthio, hydroxymethyl, CONHR.sub.11, SO.sub.2 NHR.sub.11, OR.sub.12, methoxycarbonyl, ethoxycarbonyl or NHSO.sub.2 CH.sub.3 group; PA1 R.sub.9 represents a hydrogen, fluorine or chlorine atom or a OR.sub.12 group; PA1 R.sub.10 represents a hydrogen or chlorine atom or an amino, methyl or methoxy group; PA1 R.sub.11 represents a hydrogen atom or a methyl, ethyl or hydroxyethyl group; PA1 R.sub.12 represents a hydrogen ato…