Steroid-spiro-oxathiazolidine derivatives and a process for the preparation thereof
US4342754A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 11, 1981 |
| Grant date | Aug 3, 1982 |
| Priority date | — |
| Expiry date | Mar 11, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formula (I), ##STR1## wherein R.sub.1 is a C.sub.1-3 alkyl or a C.sub.2-4 alkenyl group, and PA0 Z is a group of the formulae (II) to (VI), ##STR2## wherein R.sub.2 is methyl or ethyl, PA0 R.sub.3 is hydrogen or methyl PA0 R.sub.4 is hydrogen, a C.sub.1-3 alkyl group, a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group, a C.sub.2-4 alkylcarbonyl group, a C.sub.2-4 alkoxycarbonyl group or a C.sub.3-6 carboxyalkylcarbonyl group, and PA1 the dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, and PA1 if R.sub.4 is a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group or a C.sub.3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.