Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
US4345068A · kind A · utility
14Cited by
2References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1980 |
| Grant date | Aug 17, 1982 |
| Priority date | — |
| Expiry date | Jun 30, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for preparing the known antitumor glycosides: 4'-epidaunorubicin, 3',4'-diepidaunorubicin, and their doxorubicin analogs by oxidizing the C-4' hydroxyl group of N-protected daunorubicin to form certain novel intermediates having a 4'-keto configuration, followed by reduction of the keto group with NaBH.sub.4 and mild alkaline hydrolysis to remove the N-protecting acyl groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.