Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US4345070A · kind A · utility
11Cited by
4References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1981 |
| Grant date | Aug 17, 1982 |
| Priority date | — |
| Expiry date | Jun 5, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process for the preparation of the known 4'-deoxydaunorubicin and 4'-deoxydoxorubicin is disclosed. The used starting material is 4'-eip-N-trifluoroacetyldaunorubicin which is converted into 4'-deoxy-4'-iodo-N-trifluoroacetyl-daunorubicin from which 4'-deoxy-daunorubicin can be reductively obtained and eventually transformed, by known methods, into 4'-deoxy-doxorubicin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.