Method of delivering a therapeutic agent to a target capillary bed
US4345588A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 1980 |
| Grant date | Aug 24, 1982 |
| Priority date | — |
| Expiry date | Jun 27, 2000 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2446/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Intravascularly-administrable, magnetically-localizable biodegradable microspheres containing a therapeutic agent, such as an oncolytic agent, are prepared and administered so that they can be permanently localized in a target capillary bed for release of the therapeutic agent therein. The effects of the therapeutic agent can thereby be relatively confined to the area of the capillary bed. Of particular importance is the administration of oncolytic agents by the method, since this permits the undesirable side effects of the oncolytic agents to be substantially reduced, while at the same time increasing the anti-cancer effectiveness of the drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.