Drug delivery devices comprising erodible polymer and erosion rate modifier
US4346709A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 10, 1980 |
| Grant date | Aug 31, 1982 |
| Priority date | — |
| Expiry date | Nov 10, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08K5/098
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Erodible devices are disclosed for delivering a drug to an environment of use. The devices comprise a body sized and adapted for delivering the drug to the environment of use, which body comprises (1) a poly(orthoester) or a poly(orthocarbonate) having a repeating unit consisting of a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of the R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial drug, and (3) an erosion rate modifier. The devices are useful for delivering both locally and systemically acting drugs over a prolonged period of time. A composition of matter is also disclosed comprising the poly(orthoesters) or the poly(orthocarbonates) and an erosion rate modifier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.