Preparation of penicillanic acid derivatives
US4347182A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 1980 |
| Grant date | Aug 31, 1982 |
| Priority date | — |
| Expiry date | Mar 24, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compound 6-.beta.-chloropenicillanic acid can be prepared in substantially pure form and is a .beta.-lactamase inhibitor which may be used to enhance the effectiveness of penicillins acid cephalosporins against .beta.-lactamase producing lacteria. The process comprises the reaction of a compound of the formula: ##STR1## wherein R.sup.X is hydrogen or a carboxyl-blocking group and R is an aryl group, with a trialkyl tin hydride or a triaryl tin hydride or a dialkyl tin dihydride and optionally removing any carboxyl-blocking group R.sup.X, and/or oxidizing the atoms to an SO or SO.sub.2 ; and/or esterifying a salt of the acid to yield an in-vivo hydrolysable ester.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.