Process for the preparation of 17.alpha.-hydroxy- and 17a.alpha.-hydroxy-D-homoetiocarboxylic acids
US4348327A · kind A · utility
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10Claims
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Key dates
| Filing date | Jun 23, 1981 |
| Grant date | Sep 7, 1982 |
| Priority date | — |
| Expiry date | Jun 23, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0094
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
17.alpha.-hyroxy- and 17a.alpha.-hydroxy-D-homoetiocarboxylic acids of the formula ##STR1## wherein n is 1 or 2, PA1 A is ##STR2## and R.sub.1 is H or CH.sub.3 are prepared by hydrating the corresponding 17-nitriles with a mixture of a lower carboxylic acid and its anhydride in the presence of perchloric acid. The resultant 17.beta.-N-acylcarboxamide is then treated with an alkali metal hydroxide in a polyhydric alcohol at an elevated temperature. The product acids are intermediates, e.g., for the production of steroids having antiinflammatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.