N-Phenoxyalkylpiperidine derivatives

US4348401A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Wolfgang Kampe
• Max Thiel
• Wolfgang Schaumann · Heidelberg, DE
• Otto-Henning Wilhelms · Weinheim, DE

Key dates

• Filing date: Sep 10, 1980
• Grant date: Sep 7, 1982
• Expiry date: Sep 10, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.