Synthesis of cyclic disulfone compounds
US4348529A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1981 |
| Grant date | Sep 7, 1982 |
| Priority date | — |
| Expiry date | Aug 19, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D339/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method of synthesizing bis-sulfones of the formula ##STR1## wherein R.sup.1 and R.sup.2 each are hydrogen, alkyl, phenalkyl, phenyl or phenyl-substituted with an electron-donating or electron-withdrawing group and n is an integer 2, 3 or 4 (a) by reacting a 1,3-dithio compound with n-butyllithium to generate the anion of said compound, (b) reacting said anion with a carbonyl compound to give the 2-substituted carbonol anion intermediate, (c) reacting said intermediate with an acyl chloride or a chloroformate to give the corresponding ester, and (d) reacting said ester with a peracid to give the bis-sulfone product. The subject invention also is concerned with the novel intermediates of step (c).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.