Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline derivatives
US4349480A · kind A · utility
2Cited by
6References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 20, 1981 |
| Grant date | Sep 14, 1982 |
| Priority date | — |
| Expiry date | Feb 20, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to the preparation of 1-bromo-2-D-alkylpropanoyl-L-proline derivatives and analogous compounds which are useful as chemical intermediates to angiotensin converting enzyme (ACE) inhibitors and to the stereospecific synthesis of such ACE inhibitors having the formula: ##STR1## wherein R.sup.1 is lower alkyl and R.sup.4 and R.sup.5 are both hydrogen or together with the carbons to which they are attached represent a benzene ring optionally substituted by defined substituents. Intermediates of formula ##STR2## are also disclosed wherein R.sup.1, R.sup.4, R.sup.5 are as defined above and B.sup.+ is a cation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.