Biologically active peptides

US4350627A · kind A · utility

Assignee

• Farmitalia Carlo Erba S.p.A. · IT

Inventors

• Roberto de Castiglione · Milano, IT
• Fiorenzo Faoro · Milano, IT
• Giuseppe Perseo · Desio, IT
• Silvano Piani · Bologna, IT
• Francesco Santangelo · Milano, IT

Key dates

• Filing date: Dec 3, 1980
• Grant date: Sep 21, 1982
• Expiry date: Dec 3, 2000

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed biologically active peptides of the formula ##STR1## where X is a hydrogen atom, an N-terminus protecting group (any of an acyl-type protecting group, an aromatic urethane-type protecting group, an alkyl-type protecting group, or an alkyl urethane type protecting group), or a residue of a natural L-amino acid or a dipeptide formed of two natural L-amino acids, wherein the free amino group may be replaced by any of the foregoing N-terminus protecting groups; PA0 Y is a hydrogen atom or a protecting group for the phenolic hydroxyl group of tyrosine; PA0 A is a D-amino acid residue with a lower (thio) alkyl side chain; PA0 B is a neutral L-amino acid residue, a glycine residue, or an N-methyl amino acid residue; PA0 C is a direct bond or an amino acid or di-or tripeptide residue; and PA0 W is OH, OR, NH.sub.2, NHR, N(R).sub.2, NH-NH.sub.2, where R is an alkyl, cycloalkyl or aralkyl group of 1 to 7 carbon atoms or NHNHR' where R' is a hydrogen atom, linear or branched alkyl, cycloalkyl; alkenyl, a linear or branched or cyclic aliphatic urethane-type group, an aromatic urethane-type group normally used in polypeptide chemistry, a residue of an .alpha.-amino; .alpha.-i…