Preparation of substituted (cyclo)alkanecarboxylic acid .alpha.-cyano-3-phenoxy-benzyl esters

US4350640A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rainer Fuchs · Halver, DE
• Fritz Maurer · Wuppertal, DE
• Uwe Priesnitz · Solingen, DE
• Hans-Jochem Riebel · Bad Camberg, DE

Key dates

• Filing date: Jul 30, 1980
• Grant date: Sep 21, 1982
• Expiry date: Jul 30, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a substituted (cyclo) alkanecarboxylic acid .alpha.-cyano-3-phenoxy-benzyl ester of the formula ##STR1## in which R is alkyl or cycloalkyl optionally substituted by halogen, alkyl, cycloalkyl, alkenyl (which is optionally substituted by halogen and/or alkoxy), styryl (which is optionally substituted by halogen, and/or optionally halogen-substituted alkyl, alkoxy, alkylenedioxy and alkylthio radicals), spirocyclically linked, optionally halogen-substituted cycloalk(en)yl (which is optionally benzo-fused) or optionally substituted phenyl and PA1 R.sup.5 and R.sup.6 each independently is hydrogen or halogen, comprising adding an aqueous solution or suspension of at least an equimolar amount of a water-soluble cyanide to a mixture of an alkanecarboxylic acid chloride of the formula EQU R--CO--Cl and a 3-phenoxy-benzaldehyde of the formula ##STR2## in a hydrocarbon solvent which is virtually immiscible with water at a temperature between about 0.degree. and 80.degree. C.