Production of penicillins
US4351766A · kind A · utility
2Cited by
17References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 13, 1981 |
| Grant date | Sep 28, 1982 |
| Priority date | — |
| Expiry date | Aug 13, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1896
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.