Diagnosis of tumors or bacterial infections having .beta.-glucuronidase activity
US4351823A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Jul 18, 1980 |
| Grant date | Sep 28, 1982 |
| Priority date | — |
| Expiry date | Jul 18, 2000 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/924
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of diagnosing the presence of tumors having .beta.-glucuronidase activity comprises administering a glucuronide which differs in color or color intensity from the aglycone thereof to a patient. The preferred glucuronide is phenolphthalein glucuronide. The urine is then collecting for a twenty four hour period and the amount of phenolphthalein glucuronides present in the urine is determined. If substantially all of the phenolphthalein glucuronide is expelled then it is apparent that the body has no tumors or bacterial infections exhibiting .beta.-glucuronidase activity. If however substantial amounts of phenolphthalein is retained, then this is an indication of the presence of tumors having .beta.-glucuronidase activity or a bacterial infection having .beta.-glucuronidase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.