Process for the preparation of dipeptides
US4352752A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1981 |
| Grant date | Oct 5, 1982 |
| Priority date | — |
| Expiry date | Mar 5, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/085
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a novel process for the preparation of a dipeptide represented by the formula: ##STR1## wherein Ar represents an aromatic group; R.sup.1 represents a hydrogen atom, an alkyl group or an aryl group; R.sup.2 represents a hydrogen atom, an alkyl group or an aromatic group; Y represents a hydroxy group, an amino group or an acylamino group, which comprises subjecting a .beta.-lactam compound represented by the formula: ##STR2## wherein Ar, R.sup.1 and R.sup.2 have the same meanings as defined above, and X represents a hydroxy group, an amino group or an acylamino group, an azido group or a benzyloxy group, to hydrogenolysis in the presence of a catalyst. The process can be practiced without any complicated procedure as seen in the conventional processes for the preparation of peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.