11 .alpha.-Amino-androstanes
US4352798A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1981 |
| Grant date | Oct 5, 1982 |
| Priority date | — |
| Expiry date | Jul 15, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0011
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula ##STR1## (wherein): R.sup.1 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-7 cycloalkyl group; and PA1 R.sup.2 is a hydrogen atom, a C.sub.1-6 alkyl group or a C.sub.3-6 cycloalkyl group; and the D-homo analogues thereof having the group --CO.sub.2 R.sup.2 (wherein R.sup.2 is as defined above) at the 17a.beta.-position and salts and zwitterionic forms thereof have activity as antidysrhythmic agents and may be applicable for treatment of ventricular dysrhythmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers and excipients and may be prepared by a variety of processes known for producing steroids of this type.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.