Bicyclo[3.3.1]nonyl-benzamide

US4352802A · kind A · utility

Assignee

• Beecham Group · GB

Inventor

• Frank E. Blaney · London, GB

Key dates

• Filing date: Jun 1, 1981
• Grant date: Oct 5, 1982
• Expiry date: Jun 1, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X is oxygen or sulphur; PA0 R.sub.1 is a C.sub.1-6 alkoxy or C.sub.1-6 alkylthio group; PA0 R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, CF.sub.3, C.sub.1-7 acyl, C.sub.1-7 acylamino or amino, aminocarbonyl or aminosulphonyl optionally substituted by one or two C.sub.1-6 alkyl groups, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, hydroxy or nitro or R.sub.1 and R.sub.2 taken together are methylenedioxy or ethylenedioxy in which case R.sub.3 is any one of the groups given for R.sub.2 and R.sub.3 above; PA0 R.sub.4 is C.sub.1-7 alkyl or a group --(CH.sub.2).sub.s R.sub.5 where s is 0 to 2 and R.sub.5 is a C.sub.3-8 cycloalkyl group, or a group --(CH.sub.2).sub.t R.sub.6 where t is 1 or 2 and R.sub.6 is a phenyl group optionally substituted by one or two substituents selected from C.sub.1-6 alkyl, C.sub.1-4 alkoxy, trifluoromethyl and halogen, or a thienyl group; and PA0 n is 0 to 2; and there are at least two carbon atoms between the benzamide and heterogranatane ring nitrogen atoms, having useful pharmacological activi…