3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore
US4352808A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1980 |
| Grant date | Oct 5, 1982 |
| Priority date | — |
| Expiry date | Dec 12, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D335/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl(benzo(b)thiophenes and related derivatives having antifungal, antibacterial, and antiprotozoal activity are prepared by the reaction of the corresponding 2,3-dihydro-3-hydroxy-2-(imidazolylmethyl)benzo(b)thiophene or related derivative and an aralkyl halide. Preferred compounds are those where the aralkyl function is a hetercyclic aromatic, particularly 2-chloro-3-thenyl, and where the benzene nucleus is substituted by chlorine or fluorine. Pharmaceutical formulations comprising compounds of this invention are described, as well as the method for their use in treating microbial infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.