11.alpha.-Amino-androstanes
US4353898A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1981 |
| Grant date | Oct 12, 1982 |
| Priority date | — |
| Expiry date | Jul 15, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J63/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula ##STR1## wherein: R.sup.1 is a C.sub.1-8 alkyl group or a C.sub.3-7 cycloalkyl group; PA1 R.sup.2 is a hydrogen atom, a C.sub.1-6 alkoxy group or a C.sub.2-5 alkanoyloxy group; and PA1 R is a C.sub.1-8 alkyl group or a C.sub.3-7 cycloalkyl group; PA1 provided that when the compounds contain a 5.beta.-hydrogen atom, R.sup.2 is a hydrogen atom, and the D-homo analogues thereof having the group --CO.sub.2 R.sup.3 (wherein R.sup.3 is as defined above) at the 17a.beta.-position, and salts thereof have activity as antidysrhythmic agents and may be applicable for treatment of ventricular dysrhythmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers and excipients and may be prepared by a variety of processes known for producing steroids of this type. The invention also provides intermediates for the preparation of the compounds of formula (I), wherein R.sup.3 and/or R.sup.1 are replaced with hydrogen atoms, and processes for the preparation of such intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.