2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives, their preparation and use in treatment of depression
US4353903A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1981 |
| Grant date | Oct 12, 1982 |
| Priority date | — |
| Expiry date | Jan 15, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives of the formula: ##STR1## in which R.sub.1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, C(.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl, acetamidophenyl, thienyl, pyridyl, furyl or nitrofuryl radical, R.sub.2 represents a hydrogen atom or a (C.sub.1-4)-alkyl radical, and R.sub.3 represents a hydrogen atom or a (C.sub.1-4)-alkyl, phenyl, halogenophenyl, trifluoromethylphenyl, (C.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl or acetamidophenyl radical, and its addition salts with pharmaceutically acceptable acids are useful in therapy as antidepressants. They may be made by cyclization of compounds of the formula: ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.