6-Perhaloalkylsulfonyloxy-penicillanic acids and derivatives thereof
US4356122A · kind A · utility
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6Claims
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Key dates
| Filing date | Dec 10, 1980 |
| Grant date | Oct 26, 1982 |
| Priority date | — |
| Expiry date | Dec 10, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: ##STR1## wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R.sup.1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN.sub.2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.