Process for the preparation of halovincamone derivatives
US4356305A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1980 |
| Grant date | Oct 26, 1982 |
| Priority date | — |
| Expiry date | Aug 5, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new halovincamone derivatives of the general formula (I), ##STR1## wherein R is a C.sub.1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), ##STR2## wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.