Method and composition for controlling the growth of microorganisms
US4358443A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 1980 |
| Grant date | Nov 9, 1982 |
| Priority date | — |
| Expiry date | Aug 8, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C65/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The composition comprises certain 5-alkylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, and R is a substituted or unsubstituted n-alkyl or phenyl group of from 4 to 30 carbon atoms including substituents. The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group. The method of the invention comprises contacting a microorganism affected by the above composition with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism. The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are effective against microorganisms prevalent in dental plaque.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.