Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane
US4360700A · kind A · utility
2Cited by
2References
2Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 2, 1981 |
| Grant date | Nov 23, 1982 |
| Priority date | — |
| Expiry date | Nov 2, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/71
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane, a valuable intermediate for the preparation of analgesic agents, which comprises benzylation of 3-hydroxyacetophenone to produce 3-benzyloxyacetophenone which is converted to 1-(3-benzyloxyphenyl)-1-methylheptan-1-ol via Grignard reaction with n-hexylmagnesium bromide; chlorination of said heptanol by reaction with hydrogen chloride followed by methylation of the thus-produced 1-(3-benzyloxyphenyl)-1-chloro-1-methylheptane with trimethylaluminum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.