Retard form of pharmaceuticals with insoluble porous diffusion coatings

US4361546A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Herbert Stricker · Ingelheim am Rhein, DE
• Bernhard Freund · Gau-Algesheim, DE
• Heribert Harwalik · Ingelheim am Rhein, DE
• Karl L. Rominger · Ingelheim am Rhein, DE
• Siegfried Darda · Ingelheim am Rhein, DE
• Volkmar Haselbarth · Ingelheim am Rhein, DE
• Dietrich Arndts · Appenheim, DE
• Wolf-Dietrich Bechtel · Appenheim, DE
• Gerhard Bozler · Biberach, DE
• Rolf-Stefan Brickl
• Peter Gruber · Bottmingen, CH

Key dates

• Filing date: Jun 15, 1981
• Grant date: Nov 30, 1982
• Expiry date: Jun 15, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/4808
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, were the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.