Pyridazinone-substituted benzimidazoles and salts

US4361563A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Volkhard Austel · Biberach, DE
• Joachim Heider · Warthausen, DE
• Wolfgang Eberlein · Biberach, DE
• Willi Diederen
• Walter Haarmann

Key dates

• Filing date: May 1, 1981
• Grant date: Nov 30, 1982
• Expiry date: May 1, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto; PA1 R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl-(alkyl of 1 to 3 carbon atoms); and PA1 R.sub.3 is alkyl of 1 to 6 carbon atoms; optically active antipodes thereof; and non-toxic, pharmaceutically acceptable acid addition salts of said compounds or of said optically active antiposed. The compounds are useful as cardiotonics and antithrombotics.